A
Figure 1.
(A) 3D Cube T2 FLAIR FatSat with AIR™ Recon DL 3D, 1 x 1 x 1.2 mm, 3:40 min.; (B) 3D FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (C) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min.; (D) TRICKS.
B
Figure 1.
(A) 3D Cube T2 FLAIR FatSat with AIR™ Recon DL 3D, 1 x 1 x 1.2 mm, 3:40 min.; (B) 3D FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (C) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min.; (D) TRICKS.
C
Figure 1.
(A) 3D Cube T2 FLAIR FatSat with AIR™ Recon DL 3D, 1 x 1 x 1.2 mm, 3:40 min.; (B) 3D FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (C) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min.; (D) TRICKS.
D
Figure 1.
(A) 3D Cube T2 FLAIR FatSat with AIR™ Recon DL 3D, 1 x 1 x 1.2 mm, 3:40 min.; (B) 3D FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (C) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min.; (D) TRICKS.
A
Figure 3.
(A) 3D Cube T2 FLAIR FatSat, 1 x 1 x 1.2 mm, 3:40 min. depicting the hematoma (arrow); (B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm3, 3:16 min.; (C) 3D T1 FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (D, E) 3D ASL PLD 2525 ms plus labeling duration of (D) 1800 ms and (E) 2500 ms.
B
Figure 3.
(A) 3D Cube T2 FLAIR FatSat, 1 x 1 x 1.2 mm, 3:40 min. depicting the hematoma (arrow); (B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm3, 3:16 min.; (C) 3D T1 FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (D, E) 3D ASL PLD 2525 ms plus labeling duration of (D) 1800 ms and (E) 2500 ms.
C
Figure 3.
(A) 3D Cube T2 FLAIR FatSat, 1 x 1 x 1.2 mm, 3:40 min. depicting the hematoma (arrow); (B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm3, 3:16 min.; (C) 3D T1 FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (D, E) 3D ASL PLD 2525 ms plus labeling duration of (D) 1800 ms and (E) 2500 ms.
D
Figure 3.
(A) 3D Cube T2 FLAIR FatSat, 1 x 1 x 1.2 mm, 3:40 min. depicting the hematoma (arrow); (B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm3, 3:16 min.; (C) 3D T1 FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (D, E) 3D ASL PLD 2525 ms plus labeling duration of (D) 1800 ms and (E) 2500 ms.
E
Figure 3.
(A) 3D Cube T2 FLAIR FatSat, 1 x 1 x 1.2 mm, 3:40 min. depicting the hematoma (arrow); (B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm3, 3:16 min.; (C) 3D T1 FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (D, E) 3D ASL PLD 2525 ms plus labeling duration of (D) 1800 ms and (E) 2500 ms.
A
Figure 5.
(A) TRICKS and (B, C) 3D ASL with post labeling delay of 2525 ms and labeling duration of (B) 1800 ms and (C) 2500 ms, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
B
Figure 5.
(A) TRICKS and (B, C) 3D ASL with post labeling delay of 2525 ms and labeling duration of (B) 1800 ms and (C) 2500 ms, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
C
Figure 5.
(A) TRICKS and (B, C) 3D ASL with post labeling delay of 2525 ms and labeling duration of (B) 1800 ms and (C) 2500 ms, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
A
Figure 4.
(A, B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min., and (C, D) 3D T1 FSPGR, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
B
Figure 4.
(A, B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min., and (C, D) 3D T1 FSPGR, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
C
Figure 4.
(A, B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min., and (C, D) 3D T1 FSPGR, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
D
Figure 4.
(A, B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min., and (C, D) 3D T1 FSPGR, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
A
Figure 2.
3D ASL PLD 2525 ms with labeling duration of (A, C) 1800 ms versus (B, D) 2500 ms. In (B), note the bright spot detection (arrow) and (D) SNR improvement (circle).
B
Figure 2.
3D ASL PLD 2525 ms with labeling duration of (A, C) 1800 ms versus (B, D) 2500 ms. In (B), note the bright spot detection (arrow) and (D) SNR improvement (circle).
C
Figure 2.
3D ASL PLD 2525 ms with labeling duration of (A, C) 1800 ms versus (B, D) 2500 ms. In (B), note the bright spot detection (arrow) and (D) SNR improvement (circle).
D
Figure 2.
3D ASL PLD 2525 ms with labeling duration of (A, C) 1800 ms versus (B, D) 2500 ms. In (B), note the bright spot detection (arrow) and (D) SNR improvement (circle).
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Mathieu Rodallec, MD
Centre Cardiologique du Nord Saint-Denis, France
CASE STUDIES

Leveraging flexible label duration to improve ASL SNR performance for brain posterior fossa imaging

By Mathieu Rodallec, MD, radiologist, Saint-Joseph Hospital, Paris, France
c_Mathieu Rodallec, MD.jpg
Mathieu Rodallec, MD
Centre Cardiologique du Nord Saint-Denis, France
Posterior fossa arteriovenous malformation complicated with cerebellar hematoma is rare in elderly patients. Presented is an interesting case of spontaneous cerebellar hematoma in a 82-year-old male with positive findings using 3D arterial spin labeling (ASL).
3D ASL is a non-contrast, whole brain, quantitative perfusion assessment that is ideal for assessing stroke, transient ischemic attacks (TIAs), stenoses, and cerebrovascular and neurodegenerative diseases. However, ASL imaging of the posterior fossa is often challenging due to low signal and, therefore, does not often change the pathway in terms of the patient’s clinical management. With MR 30 for SIGNA™, a new option called Flexible Label Duration allows the ASL labeling pulse duration to go beyond the value of 1800 ms (the standard on previous software releases), up to 4000 ms. This capability helps improve perfusion signal-to-noise ratio (SNR) in ASL imaging, especially in the geriatric population who typically have a slower blood flow. Also, AIR™ Recon DL is now compatible with 3D sequences, providing an additional increase in SNR and image sharpness.
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In this clinical case, the technologist acquired two different labeling durations of 1800 ms (default) and 2500 ms. With the 2500 ms acquisition, the amount of magnetized vascular protons increases in the imaging volume, which is converted into improved SNR and better visualization of the perfusion of the brain parenchyma, especially in the cerebellum area.
Patient history
An 82-year-old male was referred to MR after diagnosis of a right cerebellum hemorrhagic stroke. The patient had no obvious underlying cause of the stroke (no history of aneurysm or vascular disease).
CS_ASL MR30 Figure 1A.jpg
A
CS_ASL MR30 Figure 1B.jpg
B
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C
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D
Figure 1. (A) 3D Cube T2 FLAIR FatSat with AIR™ Recon DL 3D, 1 x 1 x 1.2 mm, 3:40 min.; (B) 3D FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (C) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min.; (D) TRICKS.
Acquisition
The acquisition consisted of:
  • 3D Cube FLAIR + 3D T1 FSPGR pre- and post-contrast with
  • AIR™ Recon DL
  • 3D SWAN & 3D TOF with HyperSense
  • 3D ASL with Flexible Label Duration
The 48-channel Head Coil was used.
CS_ASL MR30 Figure 2A.jpg
A
CS_ASL MR30 Figure 2B.jpg
B
CS_ASL MR30 Figure 2C.jpg
C
CS_ASL MR30 Figure 2D.jpg
D
Figure 2. 3D ASL PLD 2525 ms with labeling duration of (A, C) 1800 ms versus (B, D) 2500 ms. In (B), note the bright spot detection (arrow) and (D) SNR improvement (circle).
CS_ASL MR30 Figure 3A.jpg
A
CS_ASL MR30 Figure 3B.jpg
B
CS_ASL MR30 Figure 3C.jpg
C
CS_ASL MR30 Figure 3D.jpg
D
CS_ASL MR30 Figure 3E.jpg
E
Figure 3. (A) 3D Cube T2 FLAIR FatSat, 1 x 1 x 1.2 mm, 3:40 min. depicting the hematoma (arrow); (B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm3, 3:16 min.; (C) 3D T1 FSPGR, 0.75 x 0.75 x 1 mm, 2:04 min.; (D, E) 3D ASL PLD 2525 ms plus labeling duration of (D) 1800 ms and (E) 2500 ms.
Results
The ASL with labeling duration set at 2500 ms was positive and showed some bright spots that led us to suspect a brain arteriovenous malformation underlying the hematoma in the non-contrast sequence. This suspicion was confirmed with the contrast-enhanced T1 sequence. These sequences show an intracranial venous aneurysm (Figures 2B and 5C, yellow arrow) associated with brain arteriovenous malformation (Figures 2B and 5C, blue arrow) showing abnormal venous blood flow.
CS_ASL MR30 Figure 4A.jpg
A
CS_ASL MR30 Figure 4B.jpg
B
CS_ASL MR30 Figure 4C.jpg
C
CS_ASL MR30 Figure 4D.jpg
D
Figure 4. (A, B) 3D SWAN with HyperSense, 0.6 x 0.6 x 2.5 mm, 3:16 min., and (C, D) 3D T1 FSPGR, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
CS_ASL MR30 Figure 5A.jpg
A
CS_ASL MR30 Figure 5B.jpg
B
CS_ASL MR30 Figure 5C.jpg
C
Figure 5. (A) TRICKS and (B, C) 3D ASL with post labeling delay of 2525 ms and labeling duration of (B) 1800 ms and (C) 2500 ms, depicting the aneurysm (yellow arrows) and abnormal venous flow (blue arrows).
Discussion
The new flexible labeling duration of 3D ASL and ability to attain 2500 ms improved the image quality of the fossa posterior and helped us visualize bright spots that were missed on the ASL with 1800 ms labeling duration (default value). The excellent correlation between ASL with increased labeling duration and the 3D T1 post-contrast provided the information needed to change patient management strategy. The patient was sent to the angiography room for embolization of the arteriovenous malformation.
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